Canadian Biomarker Quality Assurance: The Cutting Edge Webinar Series

Episode 1

The Triple Crown of NGS Testing in Solid Tumours: Somatic, Hereditary, cfDNA

Thursday, January 18, 2024 at 12 pm ET

Speakers

Shamini Selvarajah

Shamini Selvarajah PhD, FACMG, FCCMG
Toronto, Ontario
Clinical Molecular Geneticist, Division of Clinical Laboratory Genetics, University Health Network
Assistant Professor, Department of Laboratory Medicine & Pathobiology, University of Toronto

Dr. Shamini Selvarajah is an Assistant Professor in the University of Toronto’s Department of Laboratory Medicine and Pathobiology, and an ABMGG and CCMG dual-boarded diagnostic laboratory scientist in the Division of Genome Diagnostics at the University of Health Network. She attained her PhD at the University of Toronto, and underwent training in molecular cytogenetics at the Harvard Medical School Genetics Training Program and clinical molecular genetics at McMaster University. Her role as a clinical lab scientist includes oversight of genetic testing for oncology, including companion diagnostics, genomic test development for clinical laboratory use, and applications of next-generation sequencing in clinical care. Her translational research interests are focused on genitourinary cancer genomics, as well as the development and implementation of non-invasive genomic tests in acquired cancers through the application of high throughput technologies. Dr. Selvarajah is actively involved in the development of testing algorithms and reporting standards for molecular tests, as well as in building educational content and curricula in molecular pathology, both at the national and international levels.

Tracy Tucker PhD, FCCMG
Vancouver, British Columbia
Clinical Professor, University of British Columbia
Clinical Molecular Geneticist & Cytogeneticist, Cancer Genetics Laboratory, BC Cancer Agency

Dr. Tracy Tucker is a CCMG certified Cytogeneticist and Molecular Geneticist at the Cancer Genetic and Genomics Laboratory (CGL) at the BC Cancer Centre and is a Clinical Professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia (UBC). She received her PhD in Medical Genetics at UBC followed by clinical genetics fellowship training and Canadian College of Medical Geneticists (CCMG) certification at BC Children’s and Women’s Hospitals. In her clinical role, Dr. Tucker is focused on the identification of acquired and inherited genetic changes to diagnose cancer patients and help direct their care. She has a keen interest in transitioning high throughput technologist into the clinical laboratory for routine cancer care. Dr. Tucker has educational leadership roles, both locally and nationally, to enhance genetics training for pathology residents, undergraduate students, CCMG fellows and practicing pathologists. She is a recipient of a UBC Killam Teaching Award.

Learning Objectives

  1. Summarize the utility of multimodal NGS testing for clinical management in cancer diagnostics
  2. Identify at least one clinical scenario suitable for targeted (PCR-based) versus more comprehensive (NGS-based) molecular assays
  3. Discuss the limitations of different NGS-based analyses